84780-16-5

Upstream product

• 88-95-9 Phthaloyl dichloride 
• 64911-19-9 9-((2R,4S,5R)-4-Trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 84765-88-8 2'-deoxy-N⁶-phthaloyladenosine 

Downstream Products

• 17331-22-5 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine 
• 84780-17-6 Dithiophosphoric acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-purin-9-yl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester 

Relevant academic research and scientific papers

Nucleotides: Part LXI: Phthaloyl strategy: A new concept of oligonucleotide synthesis

A new alternative strategy of oligonucleotide synthesis was developed by use of the phthaloyl protecting group for the exocyclic amino functions of the nucleobases (see 9-12). This approach combines the advantages of cheap and easily accessible monomeric building blocks (see 17- 20), standard machine-aided oligonucleotide synthesis, and a fast deprotection protocol which is orthogonal to the cleavage procedure from the solid support. The crude oligonucleotides show high purity and require, in general, no further chromatographic purification.

Phthaloyl strategy - A new approach towards oligodeoxyribonucleotide synthesis

A new rapid strategy for machine-aided oligodeoxyribonucleotide synthesis has been established utilizing phthaloyl groups for protection of the heterocyclic amino functions within the phosphoramidite approach. A large number of DNA-sequences has been synt

PHTHA OYL GROUP: A NEW AMINO PROTECTING GROUP OF DEOXYADENOSINE IN OLIGONUCLEOTIDE SYNTHESIS

A phthaloyl group has been introduced into the N6-amino group of deoxyadenosine via silylation followed by acylation.The phthaloyl group resulted in remarkable retarding effects on depurination, while it could be removed under milder conditions than the benzoyl group.Thus, a tetradeoxy-adenylate has been successfully synthesized in high yield.