84782-15-0

Basic information

• Product Name: N-(3,5-dimethylphenyl)benzenesulfonamide
• Synonyms: N-(3,5-dimethylphenyl)benzenesulfonamide
• CAS NO: 84782-15-0
• Molecular Weight: 261.345
• Mol File: 84782-15-0.mol

Chemical Properties

• CAS DataBase Reference: N-(3,5-dimethylphenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-dimethylphenyl)benzenesulfonamide(84782-15-0)
• EPA Substance Registry System: N-(3,5-dimethylphenyl)benzenesulfonamide(84782-15-0)

Safety Data

• Hazardous Substances Data: 84782-15-0(Hazardous Substances Data)

Upstream product

• 98-10-2 benzenesulfonamide 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 99-12-7 5-nitro-m-xylene 
• 98-80-6 phenylboronic acid 
• 108-69-0 3,5-dimethylaminoaniline 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Copper-catalyzed N-arylation of sulfonamides with aryl bromides and iodides using microwave heating

The copper-catalyzed N-arylation of sulfonamides with a variety of aryl bromides and iodides using microwave heating is described.

Sequential C-S and S-N Coupling Approach to Sulfonamides

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.

Visible Light-Induced Radical Rearrangement to Construct C-C Bonds via an Intramolecular Aryl Migration/Desulfonylation Process

A highly efficient intramolecular selective aryl migration/desulfonylation of 2-bromo-N-aryl-N-(arenesulfonyl)amide via visible light-induced photoredox catalysis has been accomplished. This approach allows for the construction of a variety of multisubstituted N,2-diarylacetamide under mild reaction conditions.

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies

To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl rings and the linker joining them. Herein, we evaluated 40 bisaryl molecules based on 10 unique linker substructures to determine how these linkages influence inhibitor potency and selectivity. These linkers connect one unsubstituted aromatic ring to either a 3,5-X2 or a 3,5-X2-4-OH phenyl substructure (X = Br or CH3). Coconsideration of amyloid inhibition and ex vivo plasma TTR binding selectivity data reveal that direct connection of the two aryls or linkage through nonpolar E-olefin or -CH2CH2- substructures generates the most potent and selective TTR amyloidogenesis inhibitors exhibiting minimal undesirable binding to the thyroid hormone nuclear receptor or the COX-1 enzyme. Five high-resolution TTR·inhibitor crystal structures (1.4-1.8 A?) provide insight into why such linkers afford inhibitors with greater potency and selectivity.