84782-84-3Relevant academic research and scientific papers
Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists
Azimioara, Mihai,Alper, Phil,Cow, Christopher,Mutnick, Daniel,Nikulin, Victor,Lelais, Gerald,Mecom, John,McNeill, Matthew,Michellys, Pierre-Yves,Wang, Zhiliang,Reding, Esther,Paliotti, Michael,Li, Jing,Bao, Dingjiu,Zoll, Jocelyn,Kim, Young,Zimmerman, Matthew,Groessl, Todd,Tuntland, Tove,Joseph, Sean B.,McNamara, Peter,Seidel, H. Martin,Epple, Robert
supporting information, p. 5478 - 5483 (2015/01/09)
Systematic SAR optimization of the GPR119 agonist lead 1, derived from an internal HTS campaign, led to compound 29. Compound 29 displays significantly improved in vitro activity and oral exposure, leading to GLP1 elevation in acutely dosed mice and reduc
New macrocyclic bistriazolophanes with thioindigo chromophore
Schulz, Marvin,Christoffers, Jens
, p. 802 - 809 (2013/07/27)
Bi(4-methoxycarbonyl-3-oxothiolan-2-ylidene) derivatives are prepared by oxidative dimerization of 4- oxotetrahydrothiophene-3-carboxylates with either TPAPeNMO or K3[Fe(CN)6]. The products are obtained as mixtures of four diastereoi
Methyl 4-Oxothiolane-3-carboxylate and Methyl 2-Methyl-4-oxothiolane-3-carboxylate Anions as Synthetic Equivalents of α-Acrylate and α-Crotonate Anions. Formal Synthesis of Integerrinecic Acid
Baraldi, Pier Giovanni,Guarneri, Mario,Pollini, Gian Piero,Simoni, Daniele,Barco, Achille,Benetti, Simonetta
, p. 2501 - 2505 (2007/10/02)
The base-promoted fragmentation of the C-alkylation products (6a-h) and (8a-e) of methyl 4-oxothiolane-3-carboxylate (4) and methyl 2-methyl-4-oxothiolane-3-carboxylate (5) gave good yields of the α-substituted acrylates (7a-h) and α-substituted crotonate
A Novel α-Acrylate Anion Equivalent: A Useful Synthon for α-Substituted Acrylic Esters
Baraldi, Pier Giovanni,Barco, Achille,Benetti, Simonetta,Moroder, Fabio,Pollini, Gian Piero,et al.
, p. 1265 - 1266 (2007/10/02)
An efficient preparation of α-substituted acrylic esters is described, based on the Dieckmann-Michael retrograde reactions of the C-alkylation products of 4-methoxycarbonylthiolan-3-one (1).
