84782-94-5

Upstream product

• 67-56-1 methanol 
• 7223-50-9 N-propargylphthalimide 
• 201230-82-2 carbon monoxide 

Downstream Products

• 951172-78-4 (3S,7S)-7-benzyloxycarbonylamino-3-methoxycarbonyl-3,7-dimethyl-1,5-diazabicyclo[4.3.0]non-5-ene 
• 951172-76-2 (3R)-3-benzyloxycarbonylamino-3-methyl-1-((2RS)-3-amino-2-methoxycarbonylpropyl)pyrrolidine-2-thione 
• 951172-74-0 (3R)-3-benzyloxycarbonylamino-3-methyl-1-((2RS)-2-methoxycarbonyl-3-phthalimidopropyl)pyrrolidine-2-thione 
• 951172-71-7 methyl 3-benzylamino-2-(phthalimidomethyl)propanoate 

Relevant academic research and scientific papers

Selective Palladium-Catalyzed Carbonylation of Alkynes: An Atom-Economic Synthesis of 1,4-Dicarboxylic Acid Diesters

A class of novel diphosphine ligands bearing pyridine substituents was designed and synthesized for the first time. The resulting palladium complexes of L1 allow for chemo- and regioselective dialkoxycarbonylation of various aromatic and aliphatic alkynes affording a wide range of 1,4-dicarboxylic acid diesters in high yields and selectivities. Kinetic studies suggest the generation of 1,4-dicarboxylic acid diesters via cascade hydroesterification of the corresponding alkynes. Based on these investigations, the chemo- and regioselectivities of alkyne carbonylations can be controlled as shown by switching the ligand from L1 to L3 or L9 to give α,β-unsaturated esters.