84783-01-7

Usage

Uses

Used in Pharmaceutical Industry:
K-Ras-IN-1 is used as a targeted therapy for K-Ras mutant cancers, which are often resistant to standard treatments. Its ability to inhibit K-Ras activity makes it a potential candidate for the development of new anti-cancer drugs.
Used in Cancer Research:
K-Ras-IN-1 is used as a research tool to study the role of K-Ras in cancer development and to explore the therapeutic potential of inhibiting K-Ras activity in treating various types of cancer. Further research is being conducted to understand the mechanisms of action and to optimize the use of K-Ras-IN-1 in cancer treatment.

Upstream product

• 123-75-1 pyrrolidine 
• 90-02-8 salicylaldehyde 

Relevant academic research and scientific papers

Ruthenium(II) half-sandwich complexes containing thioamides: Synthesis, structures and catalytic transfer hydrogenation of ketones

A new family of cationic half-sandwich complexes of the type [(η6-cymene)Ru(PPh3)(L)]+ (L = bidentate monoanionic thioamide) have been synthesized and isolated as their tetraphenylborate salts. All the synthesized ruthenium(II) arene complexes are air stable and are fully characterized by elemental analysis, spectral and X-ray diffraction methods. In chloroform solution all the complexes exhibit characteristic metal to ligand charge transfer (MLCT) absorptions and ligand based transitions. Molecular structure of the complexes 2, 3 and 4 has been determined by single crystal X-ray crystallography indicates that the thioamide ligands are coordinated to ruthenium as a bidentate O, S donor and a typical piano stool geometry was observed around ruthenium(II) metal center. Complexes 1-5 were tested as catalysts in the transfer hydrogenation of aliphatic and aromatic ketones to secondary alcohols in the presence of 2-propanol/KOH. Further, the influence of base, reaction temperature and catalyst loading in this reaction was also evaluated to find out the most active catalyst.