847862-26-4

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate is used as a reagent or intermediate for the production of various pharmaceuticals. Its unique chemical properties and reactivity make it a valuable component in the synthesis of new drugs, contributing to the advancement of medicinal chemistry and the development of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate serves as a key intermediate in the synthesis of various agrochemicals. Its role in the production of these compounds is crucial for the development of effective solutions for agricultural challenges, such as pest control and crop protection.
Used in Organic Synthesis Research:
Tert-butyl(8-anti)-3-azabicyclo[3.2.1]oct-8-ylcarbamate is also utilized in research laboratories as a component in the creation of novel organic molecules. Its unique structure and reactivity make it an attractive candidate for exploring new synthetic pathways and developing innovative organic compounds with potential applications in various fields.

Upstream product

• 847862-24-2 (1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8-amine 
• 847862-25-3 exo-tert-butyl N-(3-benzyl-3-azabicyclo[3.2.1]octan-8-yl)carbamate 
• 83507-33-9 3-benzyl-3-aza-bicyclo[3.2.1]octan-8-one 
• 166973-12-2 3-benzyl-3-azabicyclo[3.2.1]octan-8-amine 
• 847795-96-4 3-benzyl-N-hydroxy-3-azabicyclo[3.2.1]octan-8-imine 

Downstream Products

• 1397286-99-5 [(rac)-8-endo-3-(3-methyl-[1,2,4]thiadiazol-5-yl)-3-aza-bicyclo[3.2.1]oct-8-yl]-[8-(2-chloro-4-fluoro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amine 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE

The present invention relates to a process for the preparation of a compound (I) or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with

BRIDGED PIPERIDINE DERIVATIVES

The present invention relates to compounds of formula (l); hetaryl I is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from S or N; hetaryl II is a six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from S or N, or is a two membered ring system containing 1 to 4 heteroatoms selected from S, or N, wherein at least one ring is aromatic in nature; R1 is lower alkyl, lower alkoxy, lower alkyl substituted by halogen or halogen; R2 is lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy, cycloalkyl substituted by lower alkyl or lower alkyl substituted by halogen, or is lower alkyl substituted by hydroxy, or is furyl, or is O-benzyl, (CH2)p-phenyl, optionally substituted by halogen, lower alkoxy, lower alkyl substituted by halogen, lower alkyl or by cyano; R3 is hydrogen or lower alkyl; Y is (CH2)n-, -CH2OCH2-, -CH2O-, CH2S-, -CH2SCH2- and is bonded to two of the ring carbon atoms, bonding being to either the ring carbon atoms a and b or the ring carbon atoms c and d; p is 0 or 1; m is 0, 1 or 2; if m is 2 then R1 may be the same or different; -75- n is 2 or 3; o is 0, 1 or 2, if o is 2, then R2 may be the same or different; or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimers disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.