847943-29-7 Usage
Description
(2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is a chemical compound with a specific stereochemical configuration, derived from pyrrolidine-2-carboxylic acid. It features a Boc (tert-butoxycarbonyl) protecting group at the N-terminal and an ethyl group attached to the 5-position of the pyrrolidine ring. (2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is widely utilized in organic synthesis and medicinal chemistry as a versatile building block for constructing more complex molecules. Its unique stereochemistry and functional groups make it a valuable component in the development of pharmaceuticals and biologically active compounds.
Uses
Used in Organic Synthesis:
(2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is used as a building block for the synthesis of complex organic molecules. Its specific stereochemistry and functional groups facilitate the creation of a diverse range of compounds with various applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is used as a key component in the development of pharmaceuticals and biologically active compounds. Its unique structural features and functional groups enable the design and synthesis of novel therapeutic agents with potential applications in various medical conditions.
Used in Drug Development:
(2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is employed as a crucial intermediate in the synthesis of new drugs. Its specific stereochemistry and functional groups allow for the development of innovative pharmaceuticals with improved efficacy, selectivity, and safety profiles.
Used in the Pharmaceutical Industry:
Within the pharmaceutical industry, (2S,5S)-N-Boc-5-ethylpyrrolidine-2-carboxylic acid is used as a vital component in the production of various drugs. Its unique structural features and functional groups contribute to the development of novel therapeutic agents with potential applications in treating a wide range of diseases and medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 847943-29-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,9,4 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 847943-29:
(8*8)+(7*4)+(6*7)+(5*9)+(4*4)+(3*3)+(2*2)+(1*9)=217
217 % 10 = 7
So 847943-29-7 is a valid CAS Registry Number.
847943-29-7Relevant articles and documents
ANTIVIRAL COMPOUNDS
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Paragraph 0311; 0316; 0330; 0331, (2015/12/31)
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors
Miyazaki, Masaki,Naito, Hiroyuki,Sugimoto, Yuuichi,Yoshida, Keisuke,Kawato, Haruko,Okayama, Tooru,Shimizu, Hironari,Miyazaki, Masaya,Kitagawa, Mayumi,Seki, Takahiko,Fukutake, Setsuko,Shiose, Yoshinobu,Aonuma, Masashi,Soga, Tsunehiko
, p. 4319 - 4331 (2013/07/27)
We have discovered and reported potent p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold. Our lead showed strong activity in vitro, but did not exhibit antitumor efficacy in vivo for the low metabolic stability. In order to obtain orally active compounds, we executed further optimization of our lead by the improvement of physicochemical properties. Thus we furnished optimal compounds by introducing an alkyl group onto the pyrrolidine at the C-2 substituent to prevent the metabolism; and modifying the terminal substituent of the proline motif improved solubility. These optimal compounds exhibited good PK profiles and significant antitumor efficacy with oral administration on a xenograft model using MV4-11 cells having wild type p53.
PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)
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Page/Page column 70, (2008/06/13)
The present invention relates to compounds of formula (I), (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, b-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.
