847952-24-3

Upstream product

• 790703-49-0 (R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-(hydroxymethyl)-oxazolidin-2-one 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 926279-48-3 (5R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-tetrazol-1-ylmethyl-oxazolidin-2-one 
• 926279-37-0 (5R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-pyrazol-1-ylmethyl-oxazolidin-2-one 
• 847952-25-4 (5R)-5-azidomethyl-3-(4-benzyloxy-3-fluoro-phenyl)-oxazolidin-2-one 

Relevant academic research and scientific papers

NOVEL ANTIBACTERIAL COMPOUNDS

The invention relates to novel chimeric antibiotics of formula (I) Wherein R1 is CH2NHCOR5, heteroarylmethyl, heteroaryloxymethyl or heteroarylaminomethyl; R2 is H, OH, OSO3H, OPO3H2, OCH2OPO3H2, OCOCH2CH2COOH, OCOR6; R3 is H or halogen; R4 is (C1-C3)alkyl, (C1-C3)haloalkyl or cycloalkyl; R5 is alkyl or haloalkyl; and R6 is the residue of a naturally occurring amino acid or of dimethylaminoglycine. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).

INTERMEDIATE PRODUCTS FOR PRODUCING OXAZOLIDINONE-QUINOLONE HYBRIDS

The invention relates to intermediate products (ZP) for a novel and efficient synthesis of compounds, wherein the pharmacophores of quinolone and oxazolidinone are linked together by means of a chemically stable linker.