84799-87-1Relevant articles and documents
Synthesis of N-(1-carboxy-3-phenylpropen-2-yl)alanylproline
Slavinskaya,Chipens,Katkevich,Sile,Korchagova,Grigor'eva,Lukevits
, p. 405 - 407 (1996)
A method has been developed for the synthesis of N-(1-carboxy-3-phenylpropen-2-yl)alanylproline by reductive alkylation of alanylproline by the sodium salt of 2-oxo-4-phenylbutertoic acid, using sodium cyanoborohydride and sodium borohydride as reducing agents. The products were separated chromatographically, Under the conditions of the reaction, sodium borohydride in a neutral medium preferentially reduces the double bond of the Schiff base. Sodium cyanoborohydride reduces, in addition, the double bond of the 2-oxo-4-phenylbutenoic acid, forming enalaprilate. 1996 Plenum Publishing Corporation.
ANTIHYPERTENSIVE COMPOSITION
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, (2008/06/13)
A pharmaceutical composition is disclosed which comprises the combination of interphenylene 9-thia-11-oxo-12-aza prostanoic acid derivatives and carboxyalkyl dipeptide derivatives.