847990-40-3

Upstream product

• 93118-03-7 2-chloro-3-trifluoromethylbenzaldehyde 
• 2380-94-1 1H-indol-4-ol 
• 612499-61-3 (3-bromopropyl)({ [2-chloro-3-(trifluoromethyl)phenyl]methyl})(2,2-diphenylethyl)amine 

Downstream Products

• 847991-18-8 2-(4-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)-1H-indol-1-yl)acetic acid 
• 847991-29-1 (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1-methyl-1H-indol-4-yloxy)-propyl]-amine trifluoroacetate 
• 847990-59-4 (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(3-(1-methanesulfonyl-1H-indol-4-yl)oxy)-propyl]-amine trifluoroacetate 

Relevant academic research and scientific papers

Synthesis and SAR of potent LXR agonists containing an indole pharmacophore

A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRα will be disclosed.

COMPOUNDS AND METHODS

Disclosed are compounds and pharmaceutically acceptable salts thereof, useful as LXR agonists.