(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Base Information

Chemical Name:(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine
CAS No.:847990-40-3
Molecular Formula:C₃₃H₃₀ClF₃N₂O
Molecular Weight:563.062
Hs Code.:

Synonyms:(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

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Chemical Property of (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

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Technology Process of (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

There total 2 articles about (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2380-94-1
1H-indol-4-ol

: 612499-61-3
(3-bromopropyl)({ [2-chloro-3-(trifluoromethyl)phenyl]methyl})(2,2-diphenylethyl)amine

: 847990-40-3
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Guidance literature:: With potassium carbonate; In acetonitrile; at 90 ℃;
DOI:10.1016/j.bmcl.2009.01.004

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 847990-40-3
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

2: potassium carbonate / acetonitrile / Heating / reflux

3: potassium carbonate / acetonitrile / 90 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In dichloromethane; acetonitrile;

Reference yield: 100.0%

: 847990-40-3
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine

: 76-05-1
trifluoroacetic acid

: 74-88-4
methyl iodide

: 847991-29-1
(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1-methyl-1H-indol-4-yloxy)-propyl]-amine trifluoroacetate

Guidance literature:: (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine; methyl iodide; With sodium hydride; In N,N-dimethyl-formamide;

trifluoroacetic acid; In water; acetonitrile;