847994-45-0

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(azidomethyl)-4-hydroxy-, phenylmethyl ester, (2S,4R)-
• CAS NO: 847994-45-0
• Molecular Formula: C13H16N4O3
• Molecular Weight: 276.295
• Mol File: 847994-45-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(azidomethyl)-4-hydroxy-, phenylmethyl ester, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(azidomethyl)-4-hydroxy-, phenylmethyl ester, (2S,4R)-(847994-45-0)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(azidomethyl)-4-hydroxy-, phenylmethyl ester, (2S,4R)-(847994-45-0)

Safety Data

• Hazardous Substances Data: 847994-45-0(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 95687-41-5 (2S,4R)-N1-(benzyloxycarbonyl)-4-hydroxy-2-(hydroxymethyl)-pyrrolidine 
• 792916-37-1 (2S,4R)-N₁-(benzyloxycarbonyl)-4-hydroxy-2-(p-toluenesulfonyloxymethyl)-pyrrolidine 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 847994-36-9 (2S,4R)-N₁-(benzyloxycarbonyl)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxy-pyrrolidine 
• 847994-39-2 ethyl 3-[(2S,4S)-2-(tert-butoxycarbonylaminomethyl)-4-(N³-benzoyl-thymin-1-yl)-pyrrolidin-1-yl]-propanoate 
• 500733-24-4 (2S,4R)-2-(tert-butyloxycarbonylaminomethyl)-4-hydroxypyrrolidine 
• 847994-48-3 (2S,4R)-N₁-(benzyloxycarbonyl)-4-hydroxy-2-(aminomethyl)-pyrrolidine 

Relevant articles and documents

Synthesis of trans-L/D-2-(tert-butoxycarbonylaminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acid

To delineate the binding preferences of stereochemically divergent pyrrolidine PNAs, synthesis of all four diastreomeric monomers of I and the systematic complexation studies of the resultant PNAs with complementary DNA/ RNA is essential. We herein report the synthesis of trans-L/D-2-(tert-butoxycarbonylaminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acids I, their incorporation in PNA oligomers and DNA binding studies will be presented.

Backbone-extended pyrrolidine peptide nucleic acids (bepPNA): Design, synthesis and DNA/RNA binding studies

One-carbon extended conformationally constrained pyrrolidine PNA monomer (bepPNA) has been synthesized, incorporated into PNA sequences at predefined positions, and showed selective RNA binding properties.