848027-99-6Relevant articles and documents
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00920; 001832; 001835-001836, (2021/01/23)
The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
Highly efficient catalytic dehydrative S-allylation of thiols and thioic S-acids
Tanaka, Shinji,Pradhan, Prasun Kanti,Maegawa, Yusuke,Kitamura, Masato
supporting information; experimental part, p. 3996 - 3998 (2010/07/06)
A SH-selective allylation method using [CpRu(2-quinolinecarboxylato) (η3-C3H5)]PF6 has been realized in various solvents including aqueous media to give allyl sulfides and allyl S-thioates, demonstrating the potential applicability to lipopeptide chemistry.