848047-72-3

Upstream product

• 100-39-0 benzyl bromide 
• 848047-64-3 (2R,3S)-3,5,7,3',4'-penta-O-benzyl-8-formyl-6-hydroxyflavan 
• 85443-49-8 (2R,3S)-3,5,7-tris(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)chroman 
• 100-44-7 benzyl chloride 
• 20728-73-8 5,7,3',4'-tetra-O-benzyl-(+)-catechin 
• 154-23-4 catechin 
• 89385-18-2 3,5,7,3',4'-penta-O-benzyl-8-formylcatechin 

Downstream Products

• 848154-70-1 (2R,3S)-2,5,6,7,8,3',4'-heptahydroxyflavan 
• 848047-73-4 (2R,3S)-3,5,6,7,3',4'-hexa-O-benzyl-8-hydroxyflavan 

Relevant academic research and scientific papers

COMPOSITION FOR ENHANCING SKIN ELASTICITY OR IMPROVING SKIN WRINKLES COMPRISING HEPTAHYDROXYFLAVAN AS AN EFFECTIVE INGREDIENT

Heptahydroxyflavan or a salt, isomer, hydrate or solvate thereof, which is an active ingredient of the present disclosure, can enhance skin elasticity and improve skin wrinkles by inhibiting the activity of MMP-1. In addition, the heptahydroxyflavan or a salt, isomer, hydrate or solvate thereof, which is an active ingredient of the present disclosure, can be used in various compositions such as cosmetics, health functional foods, etc. because it is safe with no cytotoxicity.

Hydroxylation of ring A of flavan-3-ols: Influence of the ring A substitution pattern on the oxidative rearrangement of 6-hydroxyflavan-3-ols

A general procedure for the oxidation of catechin derivatives is described, leading to the introduction of a new hydroxyl group at C-6. This procedure has been used for the synthesis of a number of 6-hydroxy flavan-3-ols, including elephantorrhizol, a natural flavan-3-ol exhibiting a fully substituted A ring. The substitution at C-8, albeit of poor influence on the course of this oxidation reaction, has been demonstrated to be preponderant for the further spontaneous oxidation and rearrangement of 6-hydroxy-flavan-3-ols into p-benzoquinones. The whole procedure allows the preparation of 6-alkyl substituted benzoquinones derived from catechin. Georg Thieme Verlag Stuttgart.

Synthesis of modified proanthocyanidins: Easy and general introduction of a hydroxy group at C-6 of catechin; efficient synthesis of elephantorrhizol

A general procedure for the oxidation of catechin derivatives is described, leading to the introduction of a new hydroxy group at C-6. This procedure has been applied for the synthesis of elephantorrhizol, a natural flavan-3-ol exhibiting a fully substitu