848072-87-7

Upstream product

• 848072-79-7 [1-(3-benzyloxy-phenyl)-2-bromo-ethoxy]-tert-butyl-dimethyl-silane 
• 884330-84-1 (R)-1-(3-Benzyloxy-phenyl)-2-bromo-ethanol 
• 100-39-0 benzyl bromide 
• 121-71-1 3-Hydroxyacetophenone 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 884331-12-8 methanesulfonic acid 3-{2-[2-(3-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethylamino]-propyl}-1H-indol-7-yl ester 

Relevant academic research and scientific papers

Tryptamine-based human β3-adrenergic receptor agonists. Part 3: Improved oral bioavailability via modification of the sulfonamide moiety

The continued SAR investigation of tryptamine-based human β3-adrenergic receptor (AR) agonists is reported. Prior efforts resulted in the identification of 2 as a potent β3-AR agonist. Further modification of the left side arylsulfonamide portion in 2 provided compounds with good cell permeability, which have potent agonistic activity for β3-AR. Cinnamylamine analog 16i exhibited an excellent agonistic profile in vitro and good oral bioavailability in rats.