84808-71-9Relevant academic research and scientific papers
The Cemistry of Amino Oximes, XVI. - The Properties of 2-Pyrimidone N-Oxide Derivatives
Gnichtel, Horst,Knapp-Artmann, Ursula,Gau, Boun Pa
, p. 107 - 111 (2007/10/02)
By reaction of anti-β-amino ketoximes 1a-d with phosgene, 2-pyrimidone N-oxide derivatives 2a-d are formed as intermediates which react in different ways.By tautomerisation of 2a the 3,6-dihydro-3-hydroxy-2(1H)-pyrimidinone derivative 3a and by addition of water to 2b the 3,4,5,6-tetrahydro-3,4-dihydroxy-2(1H)-pyrimidinone 3b is formed. 1,3-Dipolar cycloaddition of the 2-pyrimidone N-oxide 2c to the tautomeric ene-hydroxylamine 3c yields the spiro compound 4.By cycloaddition od the N-oxide 2d the pentacyclic ring system 6 is formed.
