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848086-44-2

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848086-44-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 848086-44-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,0,8 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 848086-44:
(8*8)+(7*4)+(6*8)+(5*0)+(4*8)+(3*6)+(2*4)+(1*4)=202
202 % 10 = 2
So 848086-44-2 is a valid CAS Registry Number.

848086-44-2Downstream Products

848086-44-2Relevant articles and documents

Studies on the structure-activity relationship of 2′,6′- dimethyl-l-tyrosine (Dmt) derivatives: Bioactivity profile of H-Dmt-NH-CH 3

Fujita, Yoshio,Tsuda, Yuko,Motoyama, Takashi,Li, Tingyou,Miyazaki, Anna,Yokoi, Toshio,Sasaki, Yusuke,Ambo, Akihiro,Niizuma, Hideko,Jinsmaa, Yunden,Bryant, Sharon D.,Lazarus, Lawrence H.,Okada, Yoshio

, p. 599 - 602 (2007/10/03)

The 2′,6′-dimethyl-l-tyrosine (Dmt) enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides. To further investigate its direct influence on these opioid parameters, we developed a series of compounds (H-Dmt-NH-X). Among them, H-Dmt-NH-CH3 showed the highest affinity (Kiμ = 7.45 nM) equal to that of morphine, partial μ-opioid agonism (Emax = 66.6%) in vitro and a moderate antinociception in mice.

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