848086-52-2

Upstream product

• 74545-15-6 3,4,6-Tri-O-benzyl-2-deoxy-α-D-arabino-hexopyranose 
• 174402-45-0 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(6-benzyloxy-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 
• 160549-11-1 3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranose 
• 848086-51-1 6-Benzyloxy-3-{4-[6-benzyloxy-1-((2R,4R,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-1H-indol-3-yl]-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl}-indole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 270918-15-5 12,13-dihydro-2,10-dibenzyloxy-13-(2-deoxy-3,4,6-tri-O-benzyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-6-methyl-5,7(6H)-dione 

Relevant academic research and scientific papers

Synthesis and biological activities of NB-506 analogues modified at the glucose group

A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a β-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A β-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis of dissymmetric indolocarbazole glycosides using the Mitsunobu reaction at the glycosylation step

A novel method for the synthesis of N-glycosylated dissymmetric indolo[2,3-a]pyrrolo-[3,4-c]carbazole derivatives was developed by applying the Mitsunobu reaction to the N-glycosylation reaction of substituted indole substrates.