174402-45-0Relevant academic research and scientific papers
Processes for the preparation of indolopyrrolocarbazole derivatives
-
Example 13, (2008/06/13)
This invention relates to processes for the preparation of intermediates which are useful in the synthesis of compounds of the general formula or pharmaceutically salts thereof, wherein R1 and R2 each represent an OH group, R1/
Practical synthesis of indolopyrrolocarbazoles
Ohkubo, Mitsuru,Nishimura, Teruyuki,Jona, Hideki,Honma, Teruki,Morishima, Hajime
, p. 8099 - 8112 (2007/10/03)
A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4- c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).
