848148-18-5Relevant academic research and scientific papers
'Reverse' α-ketoamide-based p38 MAP kinase inhibitors
Montalban, Antonio Garrido,Boman, Erik,Chang, Chau-Dung,Ceide, Susana Conde,Dahl, Russell,Dalesandro, David,Delaet, Nancy G.J.,Erb, Eric,Gibbs, Andrew,Kahl, Jeff,Kessler, Linda,Lundstroem, Jan,Miller, Stephen,Nakanishi, Hiroshi,Roberts, Ed,Saiah, Eddine,Sullivan, Robert,Wang, Zhijun,Larson, Christopher J.
scheme or table, p. 5456 - 5459 (2009/05/26)
We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an α-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addition resu
CYTOKINE INHIBITORS
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Page/Page column 227, (2010/02/11)
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
