84819-46-5

Upstream product

• 116332-55-9 3-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)propan-1-one 
• 116332-52-6 4-dimethylhydrazono-4-(4-fluorophenyl)butanaldimethylacetal 
• 1155956-68-5 (E)-1-(4-fluorophenyl)-4-hydroxybut-2-en-1-one 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1267310-14-4 1-(4’-fluorophenyl)butan-1,4-diol 
• 86718-78-7 1-(4-fluorophenyl)-3-buten-1-ol 
• 459-57-4 4-fluorobenzaldehyde 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 5757-96-0 4-fluoroacetophenone-N,N-dimethylhydrazone 

Downstream Products

• 115464-92-1 2-(4-fluorophenyl)-1-(n-propyl)pyrrole 
• 110319-94-3 2-(4-fluorophenyl)-1H-pyrrole 

Relevant academic research and scientific papers

Sequential multicomponent catalytic synthesis of pyrrole-3-carboxaldehydes: Evaluation of antibacterial and antifungal activities along with docking studies

A sequential multicomponent synthesis of highly substituted pyrrole-3-carboxaldehydes has been developed under metal-free conditions. This one-pot protocol involves proline-catalyzed direct chemoselective Mannich reaction-cyclization between 1,4-ketoaldehyde and in situ generated Ar/HetAr-imines followed by aerobic oxidative-aromatization at room temperature. A series of fully substituted pyrrole-3-carboxaldehydes and other diverse fused heterocycles have been synthesized. These compounds were tested for in vitro antibacterial and antifungal activities, and the selected ones display significant activity against the tested bacterial strains with a MIC value of 16 μg mL-1, which is close to that of the standard drug chloramphenicol. The bioactivity outcome was further analyzed using docking studies.

Organocatalytic Redox Isomerization of Electron-Deficient Allylic Alcohols: Synthesis of 1,4-Ketoaldehydes

An organocatalytic redox isomerization strategy has been developed for the synthesis of 1,4-ketoaldehydes. DABCO was found to be the best catalyst for the isomerization of -hydroxy enones. With 20 mol % of DABCO as catalyst and DMSO as the solvent high yi

Copper-Catalyzed Alkylation of Nitroalkanes with α-Bromonitriles: Synthesis of β-Cyanonitroalkanes

Copper catalysis now enables the efficient C-alkylation of nitroalkanes with α-bromonitriles. Using a simple and inexpensive catalyst, this process provides access to β-cyanonitroalkanes. The method is highly tolerant of various functional groups and substitution patterns. These functionally dense products serve as orthogonally masked 1,3-diamines, which can be revealed selectively for access to differentially substituted diamines. These products can also be exploited for the formation of complex cyanoalkenes and 5-aminoisoxazoles.

NEW METHODS FOR THE SYNTHESIS OF 2-ARYLPYRROLES

Two short and efficient synthetic approaches for -mostly unknown- 2-arylpyrroles are presented.The key intermediates 3 are conveniently obtained from commercially available acetophenones 5 (method I) or benzoic acid derivatives 10, 11 (method II).