116332-54-8

Basic information

• Product Name: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE
• Synonyms: 4-Fluoro-N-methyl-N-methoxybenzamide;N-Methoxy-N-methyl-4-fluorobenzaldehyde;N-Methyl-N-methoxy-4-fluorobenzamide;Benzamide, 4-fluoro-N-methoxy-N-methyl-;4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(WXFC0878)
• CAS NO: 116332-54-8
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.181
• Mol File: 116332-54-8.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 301.553°C at 760 mmHg
• Flash Point: 136.174°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(116332-54-8)
• EPA Substance Registry System: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(116332-54-8)

Safety Data

• Hazardous Substances Data: 116332-54-8(Hazardous Substances Data)

Usage

General Description

4-Fluoro-N-methoxy-N-methylbenzamide is a chemical compound with the molecular formula C9H10FNO2. It is a benzamide derivative with a fluorine atom at the 4-position and a methoxy and methyl group attached to the nitrogen. 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE is often used in medicinal chemistry as a building block for the synthesis of pharmaceuticals and research chemicals. It has potential use as an intermediate in the production of drugs that target the central nervous system and as a precursor for the development of novel therapeutic agents. Additionally, it may also have applications in the field of organic synthesis and drug discovery.

InChI:InChI=1/C9H10FNO2/c1-11(13-2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 15226-74-1 dicobalt octacarbonyl 
• 352-34-1 4-fluoro-1-iodobenzene 
• 201230-82-2 carbon monoxide 
• 456-22-4 4-Fluorobenzoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 222306-54-9 (4-fluoro-phenyl)-(1H-indol-5-yl)-methanone 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 158876-69-8 2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone 
• 158876-70-1 2-(2-bromopyridin-4-yl)-1-(4-fluorophenyl)ethan-1-one 
• 223742-86-7 4-amino-3-(4-fluorobenzoyl)pyridine 
• 223742-89-0 4-isonicotinoyl-3-(4-fluorobenzoyl)pyridine 
• 134128-48-6 1-(4-fluorobenzoyl)cyclopropanecarbonitrile 
• 701-49-5 4-fluoro-N-methylbenzamide 
• 1262282-24-5 4-fluoro-2-iodo-N-methoxy-N-methylbenzamide 
• 215307-20-3 6?amino?2?(4?fluorophenyl)?4?benzyloxy?3?(4?pyridyl)?1H-pyrrolo[2,3?b]pyridine 
• 58472-45-0 1-(p-fluorophenyl)-2-methyl-2-propen-1-one 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 
• 217661-99-9 1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone 

Relevant articles and documents

Photochromic bi-naphthopyrans

A series of novel 3-aryl-(3,3-diaryl-3H-naphtho[2,1-b]pyran-8-yl)-3H-naphtho[2,1-b]pyrans has been accessed from 6-bromo-2-naphthol via a four step transformation. Acylation of the dianion derived from the treatment of 6-bromo-2-naphthol with n-butyllithi

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.