84828-01-3Relevant academic research and scientific papers
Triazoles XXXVI . The Arylation of 5-Amino-3-methylthio-1H-1,2,4-triazole with Activated Aryl Chlorides
Trinka, Peter,Reiter, Jozsef
, p. 1359 - 1372 (2007/10/03)
The possibility of the arylation of 5-amino-3-methylthio-1H-1,2,4-triazole (1) with different chlorobenzenes activated by a nitro group was studied.The ratio of products obtained was determined by hplc using isolated products as standards.It was stated that from among the monoarylated products 8, 9 and 10 obtained the main product is 8.However, from the reaction mixtures diarylated derivatives 11 and 12 and different by products such as 15, 16, 22, 24, 25, 27, 28, 32, 36, and 38 were also isolated.
On Triazoles. I. The reaction of N-Cyanocarbonimidodithioic Acid Diesters With Hydrazines
Reiter, J.,Somorai, T.,Jerkovich, Gy.,Dvortsak, P.
, p. 1157 - 1164 (2007/10/02)
The reaction of N-cyanocarbonimidodithioic acid di(alkyl and aralkyl)esters with different alkyl-, aralkyl- and aryl hydrazines to yield 1-substituted-3-R-thio-5-amino-1H-1,2,4-triazoles (3) and 2-substituted-3-R-thio-5-amino-2H-1,2,4-triazoles (4) was studied.Isolation of the different types of isomeric pairs of 3 and 4 helped to prove the structure of products obtained which made possible correction of some confusion in the literature.The 3 (R = H) tautomeric structure of the non-substituted derivatives was supported by comparison of their uv and cmr spectra with those of the alkylated and aralkylated derivatives 3 and 4, respectively, again correcting confusion in literature.An hplc determination of the ratio of products 3 and 4 formed in the above reactions with different hydrazines made it possible to prove the mechanism of the reaction.
