1513-50-4

Usage

Uses

Used in Pharmaceutical Industry:
(2-NITRO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (2-NITRO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE serves as an intermediate in the synthesis of agrochemicals, playing a role in the creation of new compounds that can be used in agricultural applications.
Used in Organic and Medicinal Chemistry Research:
(2-NITRO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is used as a building block in organic and medicinal chemistry research, where it aids in the development of innovative compounds with potential applications in medicine and healthcare.
Safety Note:
Due to its potential toxicity and harmful effects if ingested, inhaled, or in contact with skin, appropriate safety measures should be taken when working with and handling (2-NITRO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE. It is essential to handle and store this chemical compound with care to minimize any hazards associated with its use.

InChI:InChI=1/C7H6F3N3O2/c8-7(9,10)4-1-2-5(12-11)6(3-4)13(14)15/h1-3,12H,11H2

Upstream product

• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Downstream Products

• 126274-27-9 3-[(2-Nitro-4-trifluoromethyl-phenyl)-hydrazono]-1-piperidin-1-yl-butan-1-one 
• 185507-82-8 1-(4-Fluoro-phenyl)-4-{4-[(2-nitro-4-trifluoromethyl-phenyl)-hydrazono]-piperidin-1-yl}-butan-1-one 
• 84282-79-1 1-pivaloyl-2-<2-nitro-4-(trifluoromethyl)phenyl>hydrazinecarboxylic acid ethyl ester 
• 60418-41-9 1-(2-azido-4-trifluoromethyl-phenyl)-3,5-dimethyl-1H-pyrazole 
• 60418-61-3 2-(3,5-Dimethyl-pyrazol-1-yl)-5-trifluoromethyl-phenylamine 
• 60882-64-6 2-Acethydrazido-5-trifluoromethylanilin 
• 76982-34-8 5-Amino-4-cyan-3-methyl-1-(2-nitro-4-trifluormethylphenyl)pyrazol 
• 60418-38-4 3,5-Dimethyl-1-(2-nitro-4-trifluoromethyl-phenyl)-1H-pyrazole 
• 74990-43-5 5-Amino-4-cyan-1-(2-nitro-4-trifluormethylphenyl)pyrazol 
• 84828-01-3 5-amino-3-methylthio-1-(2-nitro-4-trifluoromethylphenyl)-1H-1,2,4-triazole 
• 84304-78-9 pivalic acid <2-(2-nitro-4-trifluoromethyl)phenyl>hydrazide 

Relevant academic research and scientific papers

Preparation and pharmacologic activity of amido- derivatives of 3-methyl-3,4-dihydro benzo- and pyrido-1,2,4-triazin-3-acetic acids

Thirteen amidoderivatives of 3-methyl-3,4-dihydro-6-R-benzo-1,2,4-triazin-3-yl-acetic acids and of 3-methyl-3,4-dihydro-pyrido [3,2-e]/[3,4-e]-1,2,4-triazin- 3-yl-acetic acids were prepared and submitted to a wide pharmacological screening. The dihydrobenzotriazine and dihydropyridotriazine moieties were endowed with a wide pharmacogenic capacity; in fact, several compounds exhibited high antiinflammatory [(I c), (I d), (II d), (V f), (VI f)], diuretic [(I f), (I g), (I h)] and antihypertensive activities [(I d), (III d)], as well as minor effects on the C.N.S.

Competitive Cyclisations of Singlet and Triplet Nitrenes. Part 8. The 1-(2-Nitrenophenyl)pyrazoles and Related Systems

The title nitrenes, derived by nitro-group deoxygenation with triethyl phosphite or by thermolysis or photolysis of the corresponding azide, have been studied.The effect of substituents (Cl, Br, OMe, NMe2, Me, CF3, and NO2) both meta and para to the nitrene has been examined as a determinant of the preferred mode of cyclisation to either a pyrazolobenzotriazole or a pyrazoloquinoxaline.Similarly, the role of solvents, sensitisers, and quenchers has been studied.Routes to the isomeric 1- and 2-(2-nitrophenyl)-4,5,6,7-tetrahydroindazoles have been defined and the literature corrected by studing the nitrene-mediated cyclisation of these products.The chemistry of the analogous 1-(2-carbenophenyl)- and the 1-(2-nitrenosulphonylphenyl)-3,5-dimethylpyrazoles has also been examined, the former giving 2-(3,5-dimethylpyrazol-1-yl)-benzaldazine and -benzyl alcohol while the latter gave products of intramolecular nitrene attack (a pyrazolobenzothiatriazine) and intermolecular reaction.Rationalisations for all the reaction pathways have been advanced.