848302-36-3

Upstream product

• 676-58-4 methylmagnesium chloride 
• 667870-42-0 (7aR,11R,13S)-11-(1H-benzotriazol-1-yl)-7a,8,10,11-tetrahydro-13-phenyl-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine 

Downstream Products

• 848302-41-0 1-[(S)-((2S,6R)-2-Methyl-6-tridecyl-piperidin-1-yl)-phenyl-methyl]-naphthalen-2-ol 
• 848302-37-4 1-[(S)-[(2S,6R)-2-methyl-6-propylpiperidyl]phenylmethyl]-2-naphthalenol 
• 848302-40-9 1-[(S)-((2S,6R)-2-Methyl-6-undecyl-piperidin-1-yl)-phenyl-methyl]-naphthalen-2-ol 
• 848302-38-5 1-[(S)-((2S,6R)-2-Methyl-6-nonyl-piperidin-1-yl)-phenyl-methyl]-naphthalen-2-ol 
• 848302-42-1 1-[(S)-((2S,6R)-2-Methyl-6-pentadecyl-piperidin-1-yl)-phenyl-methyl]-naphthalen-2-ol 

Relevant academic research and scientific papers

Nonracemic betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins

(Chemical Equation Presented) Total syntheses of enantiopure alkaloidal natural products (2S,6R)-dihydropinidine (as hydrochloride) and (2S,6R)-isosolenopsins (as hydrochlorides) were achieved in four steps and in 80-82% total yields by using a synthetic strategy of the formation-cleavage of 1,3-oxazinane. (S)-Betti base was proved to be an excellent chiral auxiliary and a novel Pd/C catalyzed N-debenzylation straightforward to amine hydrochloride was developed in the presence of CH2Cl2.