848352-53-4Relevant academic research and scientific papers
New pyridinone derivatives as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
Le Van, Kiet,Cauvin, Christine,De Walque, Stéphane,Georges, Beno?t,Boland, Sandro,Martinelli, Valérie,Demonté, Dominique,Durant, Fran?ois,Hevesi, László,Van Lint, Carine
experimental part, p. 3636 - 3643 (2010/04/29)
Several 5-ethyl-6-methyl-4-cycloalkyloxy-pyridin-2(1H)-ones were synthesized and evaluated for their anti HIV-1 activities against wild-type virus and clinically relevant mutant strains. A racemic mixture (10) with methyl substituents at positions 3 and 5
2-pyridinone derivatives, having HIV inhibiting properties
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Page/Page column 6, (2008/06/13)
The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in th
