848357-92-6 Usage
Chemical class
Thienopyrazole compounds
Function
Potent dual mTORC1/mTORC2 inhibitor
Mechanism of action
Inhibits mammalian target of rapamycin (mTOR) kinase and suppresses Akt/mTOR signaling pathway
Potential use
Antineoplastic activity
Promising results in
Preclinical studies for the treatment of various cancers
Applicable cancer types
Solid tumors and hematologic malignancies
Investigation area
Therapeutic potential and role in personalized cancer therapy
Check Digit Verification of cas no
The CAS Registry Mumber 848357-92-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,3,5 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 848357-92:
(8*8)+(7*4)+(6*8)+(5*3)+(4*5)+(3*7)+(2*9)+(1*2)=216
216 % 10 = 6
So 848357-92-6 is a valid CAS Registry Number.
848357-92-6Relevant academic research and scientific papers
THIENOPYRAZOLES
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Page/Page column 104; 108, (2008/06/13)
Thienopyrazoles, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).
