848407-64-7Relevant academic research and scientific papers
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4- tetrahydroisoquinolines
Grunewald, Gary L.,Romero, F. Anthony,Seim, Mitchell R.,Criscione, Kevin R.,Deupree, Jean D.,Spackman, Christy C.,Bylund, David B.
, p. 1143 - 1147 (2005)
3-Hydroxyethyl- and 3-hydroxypropyl-7-substituted-tetrahydroisoquinolines (9, 10, 16, and 17) were synthesized and evaluated for their phenylethanolamine N-methyltransferase (PNMT) inhibitory potency and affinity for the α2-adrenoceptor. Althou
