149193-77-1

Upstream product

• 122-78-1 phenylacetaldehyde 
• 141-78-6 ethyl acetate 

Downstream Products

• 848407-64-7 3-ethoxycarbonylamino-4-phenyl-butyric acid ethyl ester 
• 149727-56-0 ethyl β-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]benzenebutanoate 
• 820223-86-7 (S)-3-amino-4-phenylbutanoic acid 
• 131270-08-1 (R)-3-amino-4-phenylbutanoic acid 

Relevant academic research and scientific papers

Improved enzymatic syntheses of valuable β-arylalkyl-β-amino acid enantiomers

The enantioselective (E～ 200) Burkholderia cepacia-catalysed hydrolyses of β-amino esters with H2O (0.5 equiv.) in t-BuOMe or in i-Pr2O at 45 °C are described. The enantiomers of biologically relevant β-arylalkyl-substituted β-amino acids, and especially (R)-3-amino-3-(2,4,5-trifluorophenyl)butanoic acid, the intermediate of the new antidiabetic drug sitagliptine, were prepared with high enantiomeric excesses (ee≥96%) and in good yields (≥42%). The Royal Society of Chemistry 2010.

Solid-phase synthesis of β-Amino ketones and six-ring carbamates via immobilized α-alkoxycarbonylamino sulfones

(figure presented) β-Amino ketones and substituted 1,3-oxazinan-2-ones have been synthesized utilizing polymer-bound and carbamate-linked α-alkoxycarbonylamino sulfones. Key steps in the synthesis are the immobilization of the N-acylimine precursor, the Mannich-type addition of various nucleophiles, and the diastereoselective reduction of the resin-bound ketone.