848411-83-6

Basic information

• Product Name: 2-Furancarboxylic acid, 5-[[2,3-dichloro-4-[5-[1-[[[3-[[(1,1-dimethylethoxy)carbonyl]methylamino] propyl]amino]sulfonyl]-4-piperidinyl]-1-methyl-1H-pyrazol-3-yl]phenoxy] methyl]-, ethyl ester
• CAS NO: 848411-83-6
• Molecular Formula: C32H43Cl2N5O8S
• Molecular Weight: 728.694
• Mol File: 848411-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Furancarboxylic acid, 5-[[2,3-dichloro-4-[5-[1-[[[3-[[(1,1-dimethylethoxy)carbonyl]methylamino] propyl]amino]sulfonyl]-4-piperidinyl]-1-methyl-1H-pyrazol-3-yl]phenoxy] methyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furancarboxylic acid, 5-[[2,3-dichloro-4-[5-[1-[[[3-[[(1,1-dimethylethoxy)carbonyl]methylamino] propyl]amino]sulfonyl]-4-piperidinyl]-1-methyl-1H-pyrazol-3-yl]phenoxy] methyl]-, ethyl ester(848411-83-6)
• EPA Substance Registry System: 2-Furancarboxylic acid, 5-[[2,3-dichloro-4-[5-[1-[[[3-[[(1,1-dimethylethoxy)carbonyl]methylamino] propyl]amino]sulfonyl]-4-piperidinyl]-1-methyl-1H-pyrazol-3-yl]phenoxy] methyl]-, ethyl ester(848411-83-6)

Safety Data

• Hazardous Substances Data: 848411-83-6(Hazardous Substances Data)

Upstream product

• 2528-00-9 5-Chloromethyl-furan-2-carboxylic acid ethyl ester 
• 848411-81-4 [3-(4-ethynyl-piperidine-1-sulfonylamino)-propyl]-methyl-carbamic acid tert-butyl ester 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 738577-08-7 4-ethynylpiperidine 

Downstream Products

• 848411-85-8 5-[4-(5-{1-[3-(tert-butoxycarbonyl-methyl-amino)-propylsulfamoyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]-furan-2-carboxylic acid 

Relevant articles and documents

Identification of nonpeptidic small-molecule inhibitors of interleukin-2

The identification, design, and synthesis of a series of novel sulfamide- and urea-based small-molecule antagonists of the protein-protein interaction IL-2/IL-2Rα are described. Installation of a furan carboxylic acid fragment onto a low-micromolar sulfamide resulted in a 23-fold improvement in activity, providing a sub-micromolar, nonpeptidic IL-2 inhibitor (IC 50 = 0.60 μM).