848416-40-0

Basic information

• Product Name: N-[[(3S,4R)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam
• Synonyms: N-[[(3S,4R)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam
• CAS NO: 848416-40-0
• Molecular Weight: 508.682
• Mol File: 848416-40-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[[(3S,4R)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam(CAS DataBase Reference)
• NIST Chemistry Reference: N-[[(3S,4R)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam(848416-40-0)
• EPA Substance Registry System: N-[[(3S,4R)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam(848416-40-0)

Safety Data

• Hazardous Substances Data: 848416-40-0(Hazardous Substances Data)

Upstream product

• 21286-54-4 D-camphor-10-sulfonyl chloride 
• 72597-34-3 (+/-)-10-Camphorsulfonamide 
• 107869-45-4 (+)-(camphorylsulfonyl)imine 
• 100-46-9 benzylamine 
• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 
• 108448-77-7 (+)-camphorsultam 
• 127762-22-5 (E)-3-(benzyloxy)acrylic acid 
• 154581-21-2 (E)-3-benzyloxypropenoyl chloride 
• 35963-20-3 (R)-10-camphorsulfonic acid 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 320385-10-2 (E)-3-benzyloxypropenoyl-(2'S)-bornane-10,2-sultam 

Downstream Products

• 604798-42-7 (3R,4R)-(1-benzyl-4-benzyloxypyrrolidin-3-yl)methanol 

Relevant articles and documents

7-(4-SUBSTITUTED 3- CYCLOPROPYLAMINOMETHYL-1- PYRROLIDINYL) Q UINOLONECARBOXYLIC ACID DERIVATIVE

To provide novel quinolonecarboxylic acid compounds serving as safe, strong antibacterial agents that are effective against drug-resistant bacteria that are less susceptible to conventional antibacterial agents. SOLVING MEANS There are provided 7-(4-substituted-3-cyclopropylaminomethylpyrrolidinyl)quinolonecarboxylic acid derivatives (such as 1-cyclopropyl-7-[(3S,4S)-3-cyclopropylaminomethyl-4-fluoro-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid) that exhibit strong antibacterial activity against gram-positive bacteria, such as MRSA, PRSP and VRE, while being safe. The compounds are shown by the following general formula (I):

A practical large-scale synthesis of (3R,4R)-4-(Hydroxymethyl)pyrrolidin-3- ol via asymmetric 1,3-dipolar cycloaddition

(3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol (1), which is a useful intermediate for the synthesis of various bioactive molecules, has been synthesized in 51% overall yield by 1,3-dipolar cycloaddition reaction from the dipolarophile, (E)-3-benzyloxypropenoyl-(2′S)-bornane-10,2-sultam (5), and the achiral ylide precursor, N-(benzyl)-N-(methoxymethyl)-N- (trimethylsilylmethyl)amine (6), without using chromatography and the subsequent reduction with LAH and catalytic hydrogenation. The diastereomers 7 and 8 were separated by crystallization, and efficient procedures were developed for the subsequent reactions to afford 1.