848437-38-7Relevant academic research and scientific papers
Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues
Ung, Alison T.,Pyne, Stephen G.,Batenburg-Nguyen, Uta,Davis, Andrew S.,Sherif, Azlifa,Bischoff, Fran?ois,Lesage, Anne S.J.
, p. 1803 - 1812 (2005)
The conformationally restricted glutamate analogues, 4-aryl-1-amino-2- cyclopentene-1,3-dicarboxylates and their cyclopentane analogues have been prepared in a diastereoselective manner. Biological studies of 12a and 12b indicates that both compounds are modest antagonists at mGluR2.
