Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues

DOI: 10.1016/j.tet.2004.12.024

Source and publish data:

Tetrahedron p. 1803 - 1812 (2005)

Update date:2022-09-26

Topics:

Authors:

Ung, Alison T.

Pyne, Stephen G.

Batenburg-Nguyen, Uta

Davis, Andrew S.

Sherif, Azlifa

Bischoff, Fran?ois

Lesage, Anne S.J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.tet.2004.12.024

The conformationally restricted glutamate analogues, 4-aryl-1-amino-2- cyclopentene-1,3-dicarboxylates and their cyclopentane analogues have been prepared in a diastereoselective manner. Biological studies of 12a and 12b indicates that both compounds are modest antagonists at mGluR2.

Full text of DOI:10.1016/j.tet.2004.12.024

Products guided by the article

Product name:3-Cyclopentene-1,3-dicarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]-, 3-ethyl 1-methyl ester

Cas No:848437-38-7

R&D Labs maybe for 848437-38-7

Shanghai TBBMed Co.,Ltd

website:http://www.tbbmed.com

Contact:86--21-50498136

Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Synasia Inc

Contact:17316303296

Address:240 Amboy Ave
Chongqing Shuangfeng Chemical Co.,Ltd

Contact:+86-23-49850156

Address:No.663,xuanhua Rd,yongchuan,chongqing,China
Beijing Wisdom Chemicals Co., Ltd.

Contact:+86-10-52350335

Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China

Relevant to this article

Enzymatic Polyketide Chain Branching to Give Substituted Lactone, Lactam, and Glutarimide Heterocycles

Doi:10.1002/anie.201407282
(2014)
Preparation of New Nitrogen-Bridged Heterocycles. 5. Smooth Michael Additions of 2(3H)-Indolizinone Derivatives

Doi:10.1246/bcsj.55.3590
(1982)
Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro

Doi:10.1016/j.bmc.2004.12.048
(2005)
Fine-tuning furan toxicity: Fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide

Doi:10.1039/b415092a
(2005)
Asymmetric epoxidation of substituted chalcones and chalcone analogues catalyzed by α-d-glucose- and α-d-mannose-based crown ethers

Doi:10.1016/j.tetasy.2010.05.009
(2010)
Single-molecule nanosized polycyclic aromatics with alternant five- and six-membered rings: Synthesis and optical properties

Doi:10.1021/ol047625c
(2005)

Article Doi