848438-50-6

Basic information

• Product Name: 4-CHLORO-6-HYDROXYQUINAZOLINE
• Synonyms: 4-CHLORO-6-HYDROXYQUINAZOLINE;4-CHLOROQUINAZOLIN-6-OL
• CAS NO: 848438-50-6
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.59
• Mol File: 848438-50-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-CHLORO-6-HYDROXYQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-HYDROXYQUINAZOLINE(848438-50-6)
• EPA Substance Registry System: 4-CHLORO-6-HYDROXYQUINAZOLINE(848438-50-6)

Safety Data

• Hazardous Substances Data: 848438-50-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-6-HYDROXYQUINAZOLINE is used as an active pharmaceutical ingredient for its potential anti-inflammatory and anti-cancer properties. It is being studied for its efficacy in treating various diseases, such as tuberculosis and malaria.
Used in Agrochemical Industry:
4-CHLORO-6-HYDROXYQUINAZOLINE is used as a component in agrochemicals, where its biological activity can contribute to the development of new products for agricultural applications.
Used in Organic Synthesis:
4-CHLORO-6-HYDROXYQUINAZOLINE is used as a building block in organic synthesis, allowing for the creation of new compounds and materials with potential applications in various industries.
Used in Research and Development:
4-CHLORO-6-HYDROXYQUINAZOLINE is utilized in research and development efforts to explore its properties and potential applications in different fields, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 16064-10-1 6-hydroxyquinazolin-4(3H)-one 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 179688-15-4 3,4-dihydro-4-oxoquinazolin-6-yl acetate 
• 179246-11-8 4-chloroquinazoline-6-yl acetate 

Downstream Products

• 848438-51-7 tert-butyl 4-[(4-chloroquinazolin-6-yl)oxy]piperidine-1-carboxylate 
• 1213827-20-3 4-chloro-6-(butyrolactone-2-yloxy)-quinazoline 
• 50424-28-7 4-chloro-6-methoxyquinazoline 
• 179246-81-2 4-{[4-(benzyloxy)phenyl]amino}quinazolin-6-ol 

Relevant articles and documents

CYCLIC IMINOPYRIMIDINE DERIVATIVES AS KINASE INHIBITORS

Provided are cyclic iminopyridimdine compounds and their bicyclic derivatives, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to B-Raf V600E kinase.

Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1

The ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) was recently shown to promote mineralization of the aortic valve, hence, its inhibition represents a significant target. A quinazoline-4-piperidine sulfamide compound (QPS1) has been described as a specific and non-competitive inhibitor of NPP1. We report herein the synthesis and in vitro inhibition studies of novel quinazoline-4-piperidine sulfamide analogues using QPS1 as the lead compound. Of the 26 derivatives prepared, four compounds were found to have Ki 105 nM against human NPP1.

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure wherein R1, R2, R3, R4, R5, R6, Y and X are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related disease employing the above compounds is also provided.

Processes and intermediates for the preparation of N4-phenyl-quinazoline-4-amine derivatives

This invention provides compounds of Formula (I), wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS

A quinazoline derivative of the formula (I); wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.