848467-63-0Relevant academic research and scientific papers
Enantioselective total synthesis of avrainvillamide and the stephacidins
Baran, Phil S.,Hafensteiner, Benjamin D.,Ambhaikar, Narendra B.,Guerrero, Carlos A.,Gallagher, John D.
, p. 8678 - 8693 (2007/10/03)
In this article, full details regarding our total synthesis of avrainvillamide and the stephacidins are presented. After an introduction and summary of prior synthetic studies in this family of structurally complex anticancer natural products, the evoluti
Short, enantioselective total synthesis of stephacidin A
Baran, Phil S.,Guerrero, Carlos A.,Ambhaikar, Narendra B.,Hafensteiner, Benjamin D.
, p. 606 - 609 (2007/10/03)
A concise route to the heptacyclic indole alkaloid stephacidin A (1) includes a simple method for the gram-scale synthesis of substituted tryptophans, a remarkable indole annulation, and the first enolate coupling of an amide to an ester. This synthesis s
Intramolecular catalysis of amide isomerization: Kinetic consequences of the 5-NH- -N(a) hydrogen bond in prolyl peptides
Cox, Christopher,Lectka, Thomas
, p. 10660 - 10668 (2007/10/03)
The presence of an intramolecular hydrogen bond has been proposed to play a key role in the catalysis of amide isomerization by peptidylprolyl isomerases (PPIases), which are highly conserved and ubiquitous rotamase enzymes that catalyze the cis-trans iso
