216392-66-4

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-3-oxo-(9CI) is used as a pharmaceutical intermediate for its potential to be developed into new drugs. 1H-Pyrrolizine-7a(5H)-carboxylicacid,tetrahydro-3-oxo-(9CI)'s unique structure and biological activities make it a valuable candidate for further research and development, with the aim of creating novel therapeutic agents.
Used in Drug Development Research:
In the field of drug development research, 1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-3-oxo-(9CI) serves as a key compound for exploring its biological properties and potential applications. Its tetrahydro-3-oxo group is of particular interest, as it can be modified to produce derivatives with specific therapeutic effects, contributing to the advancement of medicinal chemistry.
Further investigation into the compound's properties and interactions with biological systems is necessary to fully understand its potential and to unlock its full utility in the pharmaceutical sector. This may involve synthesizing new derivatives, testing their efficacy and safety, and optimizing their pharmacokinetic and pharmacodynamic profiles.

InChI:InChI=1/C8H11NO3.ClH/c10-6-2-5-9-4-1-3-8(6,9)7(11)12;/h1-5H2,(H,11,12);1H

Upstream product

• 216392-65-3 (R)-3-Oxo-tetrahydro-pyrrolizine-7a-carboxylic acid benzyl ester 
• 157662-40-3 (R)-N-(benzoyloxycarbonyl)-allylproline methyl ester 
• 848467-63-0 (R)-2-(3-Hydroxy-propyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 

Relevant academic research and scientific papers

Intramolecular catalysis of amide isomerization: Kinetic consequences of the 5-NH- -N(a) hydrogen bond in prolyl peptides

The presence of an intramolecular hydrogen bond has been proposed to play a key role in the catalysis of amide isomerization by peptidylprolyl isomerases (PPIases), which are highly conserved and ubiquitous rotamase enzymes that catalyze the cis-trans iso