848477-26-9Relevant academic research and scientific papers
Cytosporone E: Racemic synthesis and preliminary antibacterial testing
Hall, Jeffrey D.,Duncan-Gould, Nathan W.,Siddiqi, Nasar A.,Kelly, Jennifer N.,Hoeferlin, L. Alexis,Morrison, Susan J.,Wyatt, Justin K.
, p. 1409 - 1413 (2007/10/03)
The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported.
