848485-77-8Relevant articles and documents
Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives
Yang, Zhiqi,Wong, Ella Lai-Ming,Shum, Tina Yuen-Ting,Che, Chi-Ming,Hui, Yongzheng
, p. 669 - 672 (2005)
(Chemical Equation Presented) The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can maintain cytotoxicities (IC50 = 15-18 μM) against the HeLa carcinoma cell line evaluated by standard MTT assay.