848488-74-4

Basic information

• Product Name: Morpholine-3-carboxylic acid amide
• Synonyms: Morpholine-3-carboxylic acid amide;morpholine-3-carboxamide
• CAS NO: 848488-74-4
• Molecular Formula: C5H10N2O2
• Molecular Weight: 130.1451
• Mol File: 848488-74-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 350.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.162±0.06 g/cm3(Predicted)
• PKA: 16.36±0.20(Predicted)
• CAS DataBase Reference: Morpholine-3-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine-3-carboxylic acid amide(848488-74-4)
• EPA Substance Registry System: Morpholine-3-carboxylic acid amide(848488-74-4)

Safety Data

• Hazardous Substances Data: 848488-74-4(Hazardous Substances Data)

Usage

Uses

3-Morpholinecarboxamide is derived from 3-Morpholinecarbonitrile (M723800), which is used as a reactant in the synthesis of N-methyl pyrimidone derivatives as potent and orally bioavailable HIV integrase inhibitors.

Upstream product

• 77873-76-8 morpholine-3-carboxylic acid 
• 1447972-26-0 3-morpholinecarboxylic acid methyl ester hydrochloride 
• 518047-39-7 tert-butyl 3-(aminocarbonyl)morpholine 4-carboxylate 
• 212650-43-6 4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid 

Downstream Products

• 1571212-39-9 ethyl 4-(2-bromo-4-fluorophenyl)-6-((3-carbamoylmorpholino)methyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate 

Relevant articles and documents

DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS

Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.

BETA CARBOLINES AND USES THEREOF

This invention provides beta-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, G, and x are as described in the specification. The compounds are useful for treating cancer and inflammatory disorders.