848489-46-3

Upstream product

• 123-30-8 4-amino-phenol 
• 292638-85-8 acrylic acid methyl ester 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 74772-78-4 5-(4-hydroxybenzyl)-2,4-thiazolidinedione 
• 474558-85-5 5-(4-Hydroxy-benzyl)-2-imino-thiazolidin-4-one 

Relevant academic research and scientific papers

Structural characterization of impurities in pioglitazone

In the pioglitazone bulk drug three prominent impurities I-III were detected up to concentrations of 0.1% (ranging from 0.05-0.1%) by reversed phase HPLC. These impurities were isolated from enriched mother liquor samples and characterized as 5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione (I) 5-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione (II), 2-[2-(4-bromophenoxy) ethyl-5-ethyl pyridine (III) based on their 1H, and 13C NMR, DEPT, Mass and IR spectral data. Structure elucidation and synthesis of these impurities is discussed.