848564-51-2

Upstream product

• 261524-02-1 N-[1-(3-methoxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-N-methyl-2-(4-trifluoromethyl-phenyl)-acetamide 
• 261524-26-9 [1-(3-methoxy-phenyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-carbamic acid methyl ester 
• 591-31-1 3-methoxy-benzaldehyde 
• 125190-67-2 [1-(3-Methoxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-methyl-amine 
• 7314-43-4 D-α-amino-m-methoxyphenylacetic acid 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 261524-04-3 N-[1-(3-hydroxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-N-methyl-2-(4-trifluoromethyl-phenyl)-acetamide 

Relevant academic research and scientific papers

Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists

A series of 3-substituted analogs (3) of the parent κ agonist, 1, were prepared to limit access to the central nervous system. With the exception of compound 3j, all other compounds bound to the human κ opioid receptor with high affinity (Ki =