848565-59-3Relevant academic research and scientific papers
Synthesis and cytotoxic activity of genistein derivatives
Zheng, Xing,Yao, Xu,Liu, Yunmei,Zheng, Zitong,Cao, Jianguo,Liao, Duanfang
, p. 1296 - 1306 (2010)
A series of genistein derivatives was prepared and tested in vitro against leukocythemia (HL-60), colorectal adenocarcinoma (HT-29), and human gastric adenocarcinoma (SGC-7901) cell lines. Among these derivatives, 4′,5-di-n-octoxy-7-gem-difluoromethylenegenistein, 9f, had the strongest activity against HL-60, HT-29, and SGC-7901 cells.[Figure not available: see fulltext.]
Synthesis of genistein derivatives and determination of their protective effects against vascular endothelial cell damages caused by hydrogen peroxide
Fu, Xiao-Hua,Wang, Li,Zhao, Hong,Xiang, Hong-Lin,Cao, Jian-Guo
, p. 513 - 517 (2008/09/20)
A series of genistein derivatives, prepared by alkylation and difluoromethylation, were tested for their inhibitory effects on the hydrogen peroxide induced impairment in human umbilical vein endothelial (HUVE-12) cells in vitro. The HUVE-12 cells were pr
