848565-56-0Relevant academic research and scientific papers
Efficient difluoromethylation of isoflavonoids and flavonoid under mild conditions
Huang, Yang,Wang, An-Jun,Kong, Jingjing,Lou, Yue-Guang,Li, Xiao-Fei,He, Chun-Yang
supporting information, p. 91 - 96 (2017/12/26)
A simple and efficient protocol for difluoromethylation of isoflavones, flavonoids, and coumarins has been developed. The protocol uses readily available, non-ozone-depleting and easy handling BrCF2PO(OEt)2 as difluorocarbene precursor. The reaction underwent the formation of difluorocarbene under mild reaction conditions with relatively weak base therefore demonstrates high selectivity. Application of the reaction led to difluoromethylated biologically relevant molecules.
Synthesis and cytotoxic activity of genistein derivatives
Zheng, Xing,Yao, Xu,Liu, Yunmei,Zheng, Zitong,Cao, Jianguo,Liao, Duanfang
experimental part, p. 1296 - 1306 (2011/10/12)
A series of genistein derivatives was prepared and tested in vitro against leukocythemia (HL-60), colorectal adenocarcinoma (HT-29), and human gastric adenocarcinoma (SGC-7901) cell lines. Among these derivatives, 4′,5-di-n-octoxy-7-gem-difluoromethylenegenistein, 9f, had the strongest activity against HL-60, HT-29, and SGC-7901 cells.[Figure not available: see fulltext.]
Synthesis of genistein derivatives and determination of their protective effects against vascular endothelial cell damages caused by hydrogen peroxide
Fu, Xiao-Hua,Wang, Li,Zhao, Hong,Xiang, Hong-Lin,Cao, Jian-Guo
, p. 513 - 517 (2008/09/20)
A series of genistein derivatives, prepared by alkylation and difluoromethylation, were tested for their inhibitory effects on the hydrogen peroxide induced impairment in human umbilical vein endothelial (HUVE-12) cells in vitro. The HUVE-12 cells were pr
