84858-98-0Relevant academic research and scientific papers
Ring chain transformations; X: Synthesis of condensed (ω-aminoalkyl)imidazoles by ring chain transformation
Bohrisch,Patzel,Liebscher,Maas
, p. 521 - 524 (1993)
2-Aminoazaheterocycles 1 react with lactam acetals (2,2-diethoxy-1-methylpyrrolidine, -1-methylpiperidine and -hexahydro-1-methyl-1H-azepine, 2) affording 2-lactamimino azaheterocycles 3. Reaction of the latter with CH-acidic methyl halides 4 allows a ring chain transformation via N-alkylation products 5 resulting in novel 2-[ω-(methylammonio)alkyl]imidazo[2,1-b]thiazole, -[1,2-a]pyridine and -[1,2-a]pyrimidine halides 7 and the corresponding 2-[ω-(methylamino)alkyl] compounds 8.
Lactam Acetals: Part VII-Synthesis and Biological Activities of Some Heterocyclic Amidines and Diamidines
Ahuja, Padma,Singh, Jujhar,Nigam, M. B.,Sardana, Vinod,Kar, K.,Anand, Nitya
, p. 849 - 852 (2007/10/02)
A variety of heterocyclic amidines (IIa-u) and diamidines (IIIa-o) have been synthetisized by condensation of 1-alkyl-1-aza-2-oxocycloalkane acetals (Ia-e) with substituted 2-aminopyridine, 2-aminopyrimidine, 2-aminobenzthiazole, 2-aminobenzimidazole, ethylenediamine, o-, m- and p-phenylenediamines and 2,3-diaminopyridine and subjected to broad biological screening.Some of the compounds show noteworthly diuretic and antiinflammatory activities.
