39650-82-3

Basic information

• Product Name: Pyrrolidine, 2,2-dimethoxy-1-methyl-
• Synonyms: N-methylpyrrolidone dimethyl acetal;Pyrrolidine,2,2-dimethoxy-1-methyl;N-methyl-2-pyrrolidone dimethyl acetal;2,2-dimethoxy-1-methyl-pyrrolidine
• CAS NO: 39650-82-3
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Mol File: 39650-82-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 2,2-dimethoxy-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 2,2-dimethoxy-1-methyl-(39650-82-3)
• EPA Substance Registry System: Pyrrolidine, 2,2-dimethoxy-1-methyl-(39650-82-3)

Safety Data

• Hazardous Substances Data: 39650-82-3(Hazardous Substances Data)

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 124-41-4 sodium methylate 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 117028-40-7 O-methyl-N-methylpyrrolidonium methylsulfate 

Downstream Products

• 84859-10-9 N³-[1-Methyl-pyrrolidin-(2E)-ylidene]-pyridine-2,3-diamine 
• 75256-23-4 1,3-Diphenyl-2,4-dithioxo-N-methylazacyclopentano<2,3-d>pyrimidine 
• 716-43-8 dimethyl homophthalate 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 120-94-5 1-Methylpyrrolidine 
• 1257984-23-8 4-((3R,7R,11R)-3-benzoxy-3,7,11,15-tetramethylhexadec-1-ynyl)-1,6-dimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl formate 
• 128792-79-0 4-(4-Chloro-phenyl)-1,6-dimethyl-1,2,3,6,7,8-hexahydro-dipyrrolo[2,3-b;2',3'-d]pyridine 
• 128792-87-0 4-(4-Chloro-phenyl)-1,6-dimethyl-1,6-dihydro-dipyrrolo[2,3-b;2',3'-d]pyridine 
• 128792-77-8 4-Chloro-N-[(E)-1,1'-dimethyl-[2,3']bipyrrolidinyliden-(2'Z)-ylidene]-benzamide 
• 128792-78-9 1,6-Dimethyl-4-phenyl-1,2,3,6,7,8-hexahydro-dipyrrolo[2,3-b;2',3'-d]pyridine 
• 128792-76-7 N-[(E)-1,1'-Dimethyl-[2,3']bipyrrolidinyliden-(2'Z)-ylidene]-benzamide 
• 128792-86-9 1,6-Dimethyl-4-phenyl-1,6-dihydro-dipyrrolo[2,3-b;2',3'-d]pyridine 
• 74254-91-4 3-[Hydroxy-(2-nitro-phenyl)-methyl]-1-methyl-pyrrolidin-2-one 
• 60624-06-8 3-[(2-Amino-phenyl)-hydroxy-methyl]-1-methyl-pyrrolidin-2-one 

Relevant articles and documents

Lactam acetals : Part XXIV reaction with activated haloalkyl compounds with and without zinc

Reaction of 2-alkoxyimmonium methosulfates (2), and of lactam acetals (3) derived therefrom, with α-haloesters in presence of zinc (Reformatsky condition) yielded N-alkyl-2-(α-alkyl-α-alkoxycarbonyl)methylene-l-azacycloalkanes (6), while reaction of 3 with α-haloesters without zinc gave 3-alkoxycarbonylmethyl-l-azacycloalkane-2-one (5). Similar reaction of 2 and 3 with 4-bromoethylquinolin-2-one (4) in presence of zinc gave N-alkyl-2-[4-(2-oxoquinolyl)methylene]-1-azacycloalkanes (7), a key intermediate for the synthesis of antimalarial quinoline-4-methanols.

DECITABINE ANALOGS FOR IMMUNOLOGICAL AND ONCOLOGICAL THERAPY

Novel N44-substituted decitabine analogs are disclosed that exhibit promising in vitro and in vivo therapeutic activity. These novel compounds were shown to be resistant to deamination via cytidine deaminase (CDA) metabolism and provide a unique pharmacokinetic profile versus decitabine, while retaining the ability to induce DNA demethylation in target cells. These novel compounds can be used for treating hematological cancers, as well for new therapeutic interventions, including bacterial or viral pneumonia, acute respiratory distress syndrome, pulmonary fibrosis, transplantation and checkpoint inhibitor-induced adverse events, including pneumonitis.

1H- PYRROLO [2, 3 -B] PYRIDINE DERIVATIVES AND THEIR USE AS RADICAL QUENCHERS

The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.