39650-82-3Relevant academic research and scientific papers
Lactam acetals : Part XXIV reaction with activated haloalkyl compounds with and without zinc
Jain, Sanjay,Jain, Rahul,Singh, Jujhar,Anand, Nitya
, p. 2951 - 2954 (1994)
Reaction of 2-alkoxyimmonium methosulfates (2), and of lactam acetals (3) derived therefrom, with α-haloesters in presence of zinc (Reformatsky condition) yielded N-alkyl-2-(α-alkyl-α-alkoxycarbonyl)methylene-l-azacycloalkanes (6), while reaction of 3 with α-haloesters without zinc gave 3-alkoxycarbonylmethyl-l-azacycloalkane-2-one (5). Similar reaction of 2 and 3 with 4-bromoethylquinolin-2-one (4) in presence of zinc gave N-alkyl-2-[4-(2-oxoquinolyl)methylene]-1-azacycloalkanes (7), a key intermediate for the synthesis of antimalarial quinoline-4-methanols.
DECITABINE ANALOGS FOR IMMUNOLOGICAL AND ONCOLOGICAL THERAPY
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Page/Page column 42-43, (2022/02/28)
Novel N44-substituted decitabine analogs are disclosed that exhibit promising in vitro and in vivo therapeutic activity. These novel compounds were shown to be resistant to deamination via cytidine deaminase (CDA) metabolism and provide a unique pharmacokinetic profile versus decitabine, while retaining the ability to induce DNA demethylation in target cells. These novel compounds can be used for treating hematological cancers, as well for new therapeutic interventions, including bacterial or viral pneumonia, acute respiratory distress syndrome, pulmonary fibrosis, transplantation and checkpoint inhibitor-induced adverse events, including pneumonitis.
PHOSPHOROUS PROTECTING GROUPS AND METHODS OF PREPARATION AND USE THEREOF
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Paragraph 00179, (2015/11/23)
Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupl
1H- PYRROLO [2, 3 -B] PYRIDINE DERIVATIVES AND THEIR USE AS RADICAL QUENCHERS
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Page/Page column 50; 51, (2013/08/28)
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant
Lu, Jun,Khdour, Omar M.,Armstrong, Jeffrey S.,Hecht, Sidney M.
experimental part, p. 7628 - 7638 (2011/01/04)
An efficient synthesis has provided access to a novel α-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a Stille coupling reaction was employed
Amidine Protecting Groups for Oligonucleotide Synthesis
McBride, Lincoln J.,Kierzek, Ryszard,Beaucage, Serge L.,Caruthers, Marvin H.
, p. 2040 - 2048 (2007/10/02)
Amidines have been investigated for protection of deoxyadenosine, deoxycytidine, 5-methyldeoxycytidine, cytidine, and deoxyguanosine.These amidine-protected nucleosides and their 5'-bis(p-anisylphenyl)methyl derivatives were prepared in high yield (79-100
Bis-amidines
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, (2008/06/13)
Symmetrical bis-amidine derivatives of mitomycin C may be converted to unsymmetrical bis-amidine analogs by reaction with secondary amines. The compounds are active anti-tumor agents in experimental animal tumors.
