848590-35-2Relevant academic research and scientific papers
Non-peptidic small molecule inhibitors of XIAP
Park, Cheol-Min,Sun, Chaohong,Olejniczak, Edward T.,Wilson, Alan E.,Meadows, Robert P.,Betz, Stephen F.,Elmore, Steven W.,Fesik, Stephen W.
, p. 771 - 775 (2005)
Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
