848617-65-2

Upstream product

• 848617-63-0 (E)-(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-hept-2-enoic acid ethyl ester 
• 111060-51-6 (S)-benzyl 2-(dibenzylamino)-3-methylbutanoate 
• 452920-98-8 dimethyl (3S)-[3-(dibenzylamino)4-methyl-2-oxopentyl]phosphonate 

Downstream Products

• 848617-67-4 (2R,5S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid 
• 328086-55-1 (2R,5S)-2-(4-Fluoro-benzyl)-6-methyl-5-[(5-methyl-isoxazole-3-carbonyl)-amino]-4-oxo-heptanoic acid 
• 328273-13-8 (2R,5S)-5-Amino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of ketomethylene tripeptide isosteres

A chemoenzymatic method is described for the synthesis of a desired ketomethylene tripeptide isostere. The key step is an enzymatic hydrolysis, which removes the C-terminal ester-protecting group under mild conditions without epimerizing the existing ster