848644-69-9Relevant academic research and scientific papers
Stereochemistry of hydroxylation during the conversion of α-ketoisocaproate to β-hydroxyisovalerate by 4-hydroxyphenylpyruvate dioxygenase
Adlington, Robert M.,Baldwin, Jack E.,Crouch, Nicholas P.,Lee, Meng-Huee,MacKinnon, Colin H.,Paul, Diana R.
, p. 2721 - 2724 (1996)
4-Hydroxyphenylpyruvate dioxygenase catalyzes the oxidative decarboxylation and hydroxylation of α-ketoisocaproate 1 to β-hydroxyisovalerate 2 with retention of configuration during the hydroxylation step.
A concise asymmetric synthesis of (2S,3S,7S)-3,7-dimethylpentadecan-2-yl acetate and propionate, the sex pheromones of pine sawflies
Huang, Pei-Qiang,Lan, Hong-Qiao,Zheng, Xiao,Ruan, Yuan-Ping
, p. 3964 - 3967 (2007/10/03)
(2S,3S,7S)-3,7-Dimethylpentadecan-2-yl acetate (2) and its propionate analogue (3) are the main sex pheromones of all Neodiprion species and Diprion similes, respectively. Starting from (S)-malic acid and employing a highly chemo-, regio-, and stereoselective tandem ester reduction-epoxide formation-reductive epoxide-opening reaction protocol, an efficient total synthesis of (2S,3S,7S)-2 and -3 is reported herein.
Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase
Crouch, Nicholas P.,Adlington, Robert M.,Baldwin, Jack E.,Lee, Meng-Huee,MacKinnon, Colin H.,Paul, Diana R.
, p. 10827 - 10840 (2007/10/03)
The stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate catalysed by the enzyme 4-hydroxyphenylpyruvate dioxygenase is described.
