Stereochemistry of hydroxylation during the conversion of α-ketoisocaproate to β-hydroxyisovalerate by 4-hydroxyphenylpyruvate dioxygenase

Article abstract of DOI:10.1016/S0960-894X(96)00489-1

4-Hydroxyphenylpyruvate dioxygenase catalyzes the oxidative decarboxylation and hydroxylation of α-ketoisocaproate 1 to β-hydroxyisovalerate 2 with retention of configuration during the hydroxylation step.