84873-18-7Relevant academic research and scientific papers
Contribution to the study of pristinamycines mechanism of action
Abbe,Capmau,Vindimian,Le Goffic
, p. 542 - 546 (2007/10/02)
In order to precise the mechanism of action of the pristinamycin I[A] and II[A] (PI[A] and PII[A]) and particularly to elucidate the origin of the synergy of these molecules, we have synthesized some hydrogenated analogs of these two antibiotics. Their antibiotic properties and their affinity for the bacterial ribosome which is the cible of these compounds were compared to that of the parent antibiotics. Thus, the dihydropristinamycin I[A] (allo (H2PI[A] (A)) and the dihydropristinamycin II[A] (β) (H2PII[A] (β)) which have a great similarity respectively with PI[A] and PII[A] were chosen for the previous study. With their use, it was possible to detect an increasing affinity of H2PI[A] (A) for the ribosome in the presence of PII[A] and the stabilization of the complex (H2PI[A] (A)) ribosome in the same conditions. We have also demonstrated the quasi irreversible binding of 3H2PII[A] (β) on the bacterial ribosome. This observation could explain the lasting damage produced by PII[A] on sensitive bacteria.
